PHP 5.3.3 or a newer version of PHP.
PECL/mysqlnd_qc is a mysqlnd plugin. It plugs into the mysqlnd library. To use you this plugin with a PHP MySQL extension, the extension (mysqli, mysql, or PDO_MYSQL) must enable the mysqlnd library.
For using MEMCACHE storage handler: Use libmemcache 0.38 or newer. PECL/mysqlnd_qc 1.2 has been tested with libmemcache 1.4.0.
For using sqlite storage handler: Use the sqlite3 extension that bundled with PHP.